We’re his biggest champions.

The Clarus Therapeutics team is singularly focused on men’s health.

At our core, we’re dedicated to advancing care for a specific type of hypogonadal man—those who have low to no testosterone due to certain medical conditions. We’ve made it our mission to empower men with our commitment to their health and well-being.

Not an actual patient

Revolutionizing men's health by focusing on the hypogonadal man.

Guided by vast collective experience, including a widely published author on testosterone-related topics and inventor of several testosterone-related patents, Clarus Therapeutics has focused on testosterone deficiency.

Symptoms and Signs Associated With Testosterone Deficiency
Silhouette of man with icons showing symptoms of hypogonadism

What is hypogonadism?

  • Hypogonadism is a clinical syndrome that results from a failure of the testes to produce physiological concentrations of testosterone1
  • According to current clinical guidelines from the Endocrine Society and the American Urological Association, diagnosis of hypogonadism is determined by both the identification of symptoms and/or signs consistent with the condition, and measurement of low morning total serum testosterone concentration, defined as <300 ng/dL, on 2 separate days1,2
  • Hypogonadism should not be confused with the term “low T,” which has been previously treated based solely on low testosterone numbers1
  • Untreated hypogonadism may be associated with certain comorbidities2

What causes hypogonadism?

It is important to determine the cause of hypogonadism in order to appropriately treat the underlying condition.1 There are two types of hypogonadism:

Primary hypogonadism1

  • Also known as testicular hypogonadism, results from a failure of the testes to produce normal levels of testosterone

Secondary hypogonadism1

  • Also known as pituitary-hypothalamic hypogonadism, results from dysfunction of the hypothalamus and pituitary gland

The cause of hypogonadism can be either organic or functional.1

  • Organic hypogonadism (“classic” hypogonadism) is a permanent hypothalamic, pituitary, or testicular dysfunction caused by congenital, structural, or destructive disorders
    • Examples of organic causes include Klinefelter syndrome, abnormal development of the hypothalamus, hypothalamic/pituitary tumors, and permanent injury from cancer therapy or testicular trauma (eg, injury, torsion, infection)
  • Functional hypogonadism is caused by conditions that suppress gonadotropin and testosterone concentrations but that are potentially reversible with treatment of the underlying etiology
    • Examples of functional causes include medication use, alcohol abuse, and systemic illness (eg, obesity)

What are the signs and symptoms of hypogonadism?

  • Symptoms of hypogonadism include reduced libido, diminished sexual function, hot flushes/sweats/decreased energy/motivation/initiation3
  • Signs of hypogonadism include decreased bone density, anemia, reduced muscle mass, and strength2

How is hypogonadism diagnosed?

There is a wide range of hypogonadism signs and symptoms, many of which overlap with other conditions and/or comorbidities, making diagnosis challenging.1 According to clinical guidelines, diagnosis of hypogonadism is determined by both the identification of symptoms and/or signs consistent with hypogonadism and blood test measurement of low morning total serum testosterone concentration, defined as <300 ng/dL, on 2 separate days.1,2

Who is a candidate for testosterone replacement therapy?

Men who show symptoms and/or signs consistent with the condition, and who had a measurement of low morning total serum testosterone concentration of <300 ng/dL on 2 separate days, should discuss treatment options with a healthcare provider.2

  1. Bhasin S, Brito JP, Cunningham GR, et al. Testosterone therapy in men with hypogonadism: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2018;103(5):1715-1744.
  2. Mulhall JP, Trost LW, Brannigan RE, et al. Evaluation and management of testosterone deficiency: AUA guideline. J Urol. 2018;200(2):423-432.
  3. Sumko D, Stoutt W, Weis SE, Wong L. Congenital idiopathic hypogonadotropic hypogonadism: a case report. J Clin Case Rep. 2014;4(6):371.